|  | 11 Mar | 17:30 EAT | Darmstadt vs 1. FSV Mainz 05 | 2-1 | X |
| | 11 Mar | 17:30 EAT | SC Freiburg vs Hoffenheim | 1-1 | 1X |
| | 11 Mar | 18:00 EAT | Bournemouth vs West Ham | 3-2 | 1 |
| | 11 Mar | 18:00 EAT | Hull City vs Swansea | 2-1 | 1X |
| | 11 Mar | 20:30 EAT | Ingolstadt vs FC Koln | 2-2 | X |
| | 11 Mar | 22:00 EAT | Nancy vs Lille | 1-2 | X |
| | 11 Mar | 22:00 EAT | Montpellier vs Nantes | 2-3 | 1X |
| | 11 Mar | 22:45 EAT | Genoa vs Sampdoria | 0-1 | 1X |
| | 12 Mar | 14:00 EAT | Real Sociedad vs Ath Bilbao | 0-2 | 1 |
| | 12 Mar | 17:00 EAT | Chievo vs Empoli | 4-0 | 1 |
| | 12 Mar | 17:00 EAT | Pescara vs Udinese | 1-3 | 1X |
| | 12 Mar | 19:30 EAT | Hamburger SV vs B. Monchengladbach | 2-1 | 2 |
| | 12 Mar | 20:30 EAT | Celta Vigo vs Villarreal | 0-1 | 1 |
