| Home – Away | Score | FT | UO | ||
|---|---|---|---|---|---|
 | St. Liege vs Gent 16 Dec – 20:00 EAT – Belgium – Jupiler League | 0-0 | X | U | |
 | Sandecja Nowy S. vs Lechia Gdansk 16 Dec – 20:00 EAT – Poland – Ekstraklasa | 2-2 | 2 | U | |
 | Eibar vs Valencia 16 Dec – 20:30 EAT – Spain – LaLiga | 2-1 | 1 | O | |
 | Willem II vs Zwolle 16 Dec – 20:30 EAT – Netherlands – Eredivisie | 2-3 | 2 | U | |
 | Admira vs Altach 16 Dec – 20:30 EAT – Austria – Tipico Bundesliga | 3-1 | 1 | O | |
| Eupen vs St. Truiden 16 Dec – 22:00 EAT – Belgium – Jupiler League | 0-0 | 1 | O | |
| Twente vs Vitesse 16 Dec – 22:45 EAT – Netherlands – Eredivisie | 1-1 | X | U |