| Home – Away | Score | FT | UO | ||
|---|---|---|---|---|---|
 | Leonesa vs Gimnastic 17 Dec – 20:00 EAT – Spain – LaLiga2 | 2-0 | 1 | O | |
 | Benevento vs Spal 17 Dec – 20:00 EAT – Italy – Serie A | 1-2 | 1 | U | |
 | Charleroi vs Genk 17 Dec – 20:00 EAT – Belgium – Jupiler League | 1-1 | 1 | U | |
 | Delfin vs Emelec 17 Dec – 20:00 EAT – Ecuador – Serie A | 0-2 | X | U | |
| Las Palmas vs Espanyol 17 Dec – 20:30 EAT – Spain – LaLiga | 2-2 | 1 | O | |
 | Petrolero de Yacuiba vs Blooming 17 Dec – 22:00 EAT – Bolivia – Liga de Futbol Prof | 1-1 | 1 | U | |
| Atalanta vs Lazio 17 Dec – 22:45 EAT – Italy – Serie A | 3-3 | 1 | O |