| Home – Away | Score | #1 | #2 | #3 | ||
|---|---|---|---|---|---|---|
| 1 – Scunthorpe vs Bradford City 09/01/2021 – 18:00 GMT+3 – England – League Two | Postp | 2 | 2 | 2 | ||
| 2 – Mirandes vs Rayo Vallecano 09/01/2021 – 18:00 GMT+3 – Spain – LaLiga2 | Postp | X | 2 | X | ||
| 3 – Genoa vs Bologna 09/01/2021 – 20:00 GMT+3 – Italy – Serie A | 2-0 | 2 | 1 | 1 | ||
| 4 – Moreirense vs Guimaraes 09/01/2021 – 20:00 GMT+3 – Portugal – Primeira Liga | 2-2 | 2 | 2 | 2 | ||
| 5 – Malaga vs Oviedo 09/01/2021 – 20:15 GMT+3 – Spain – LaLiga2 | 1-1 | 1 | X | X | ||
| 6 – RB Leipzig vs Dortmund 09/01/2021 – 20:30 GMT+3 – Germany – Bundesliga | 1-3 | 1 | 1 | 2 | ||
| 7 – Cercle Brugge vs Eupen 09/01/2021 – 20:30 GMT+3 – Belgium – Jupiler League | 1-2 | 2 | 2 | 1 | ||
| 8 – Sunderland vs Hull 09/01/2021 – 22:45 GMT+3 – England – League One | 1-1 | 2 | 1 | 2 | ||
| 9 – Oostende vs Charleroi 09/01/2021 – 22:45 GMT+3 – Belgium – Jupiler League | 3-2 | 1 | 1 | 1 | ||
| 10 – Lens vs Strasbourg 09/01/2021 – 23:00 GMT+3 – France – Ligue 1 | 0-1 | 2 | 2 | 1 | ||
| 11 – Metz vs Nice 09/01/2021 – 23:00 GMT+3 – France – Ligue 1 | 1-1 | 2 | X | X | ||
| 12 – Reims vs St Etienne 09/01/2021 – 23:00 GMT+3 – France – Ligue 1 | 3-1 | 1 | 1 | 2 | ||
| 13 – Boavista vs Santa Clara 09/01/2021 – 23:30 GMT+3 – Portugal – Primeira Liga | 1-1 | 1 | 2 | 1 |