| | 1 – Cobresal vs Audax Italiano
04/10/2021 – 17:00 GMT+3 – Chile – Primera Division | 1-2 | 1.65 | FT | 1 |
| | 2 – Esbjerg vs HB Koge
04/10/2021 – 20:00 GMT+3 – Denmark – 1st Division | 2-0 | 1.25 | DC | 1X |
| | 3 – Brage vs Osters
04/10/2021 – 20:00 GMT+3 – Sweden – Superettan | 2-2 | 3.10 | FT | X |
| | 4 – Crusaders vs Coleraine
04/10/2021 – 21:45 GMT+3 – Northern Ireland – NIFL Premiership | 0-2 | 1.25 | DC | 12 |
| | 5 – Juve Stabia vs Palermo
04/10/2021 – 22:00 GMT+3 – Italy – Serie C – Group C | 0-0 | 2.85 | FT | X |
| | 6 – Girona vs Almeria
04/10/2021 – 22:00 GMT+3 – Spain – LaLiga2 | 1-2 | 1.40 | DC | X2 |
| | 7 – Annecy vs Villefranche
04/10/2021 – 22:00 GMT+3 – France – National | 2-0 | 1.25 | DC | 1X |
| | 8 – Trofense vs Nacional
04/10/2021 – 22:15 GMT+3 – Portugal – Liga Portugal 2 | 0-3 | 2.35 | FT | 2 |
| | 9 – Defensa y Justicia vs Talleres
05/10/2021 – 00:00 GMT+3 – Argentina – Liga Profesional | 3-0 | 1.40 | DC | X2 |
| | 10 – Melipilla vs Santiago W.
05/10/2021 – 00:30 GMT+3 – Chile – Primera Division | 1-1 | 2.55 | FT | 2 |
| | 11 – Colon vs Banfield
05/10/2021 – 02:15 GMT+3 – Argentina – Liga Profesional | 0-0 | 3.05 | FT | X |
| | 12 – Huachipato vs Curico Unido
05/10/2021 – 03:00 GMT+3 – Chile – Primera Division | 1-4 | 3.20 | FT | X |
| | 13 – Trelleborgs vs Landskrona
05/10/2021 – 20:00 GMT+3 – Sweden – Superettan | 2-2 | 1.90 | FT | 1 |
| | 14 – Vasteras vs GAIS
05/10/2021 – 20:00 GMT+3 – Sweden – Superettan | 3-0 | 1.25 | DC | 12 |
| | 15 – Corinthians vs Bahia
06/10/2021 – 03:30 GMT+3 – Brazil – Serie A | 3-1 | 1.80 | FT | 1 |
| | 16 – Nagoya GE vs Tokyo
06/10/2021 – 13:00 GMT+3 – Japan – YBC Levain Cup | 3-1 | 2.00 | FT | 1 |
