| | 01 Apr | 17:00 EAT | Aston Villa vs Norwich | 2-0 | 1 |
| | 01 Apr | 17:00 EAT | Ipswich vs Birmingham | 1-1 | X |
| | 01 Apr | 17:00 EAT | Wolves vs Cardiff | 3-1 | 1 |
| | 01 Apr | 17:00 EAT | Brentford vs Bristol City | 2-0 | 1 |
| | 01 Apr | 17:00 EAT | Hull City vs West Ham | 2-1 | 1X |
| | 01 Apr | 17:00 EAT | Leicester vs Stoke City | 2-0 | 1 |
| | 01 Apr | 19:30 EAT | Reading vs Leeds | 1-0 | X |
| | 01 Apr | 19:30 EAT | Eintracht Frankfurt vs B. Monchengladbach | 0-0 | 1X |
| | 01 Apr | 20:00 EAT | Bastia vs Lille | 0-1 | X2 |
| | 01 Apr | 22:00 EAT | Monaco vs Paris SG | 1-4 | 2 |
| | 01 Apr | 22:30 EAT | Benfica vs FC Porto | 1-1 | 1X |
| | 02 Apr | 15:30 EAT | Swansea vs Middlesbrough | 0-0 | 1 |
| | 02 Apr | 16:00 EAT | Palermo vs Cagliari | 1-3 | 1 |
| | 02 Apr | 16:30 EAT | Ingolstadt vs 1. FSV Mainz 05 | 2-1 | 1 |
| | 02 Apr | 18:00 EAT | Arsenal vs Manchester City | 2-2 | X2 |
| | 02 Apr | 21:45 EAT | Napoli vs Juventus | 1-1 | X |
| | 02 Apr | 22:00 EAT | Nice vs Bordeaux | 2-1 | 1 |